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If the QT interval prolongs to 500 msec or greater, the dose must be reduced or the drug discontinued.
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Its primary use is in management of digitalis-induced arrhythmias, because it abolishes digitalis-induced abnormal automaticity.
Due to landmark trials such as the Comparison of Medical, Pacing, and Defibrillation Therapies in Heart Failure (COMPANION) trial, the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), and the Multicenter Automated Defibrillator Implantation Trial (MADIT), the standard of care has been expanded to include not only pharmacologic therapy, but also device therapy via implantable cardioverter-defibrillators (ICDs) with and without biventricular pacemakers.
There is a direct relationship between renal function, as measured by serum creatinine or creatinine clearance, and the elimination rate of sotalol hydrochloride tablets (AF).
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Thirteen of the 16 patients who were discharged taking oral sotalol were free of symptomatic recurrences during a median of 36 months of follow-up.
Sotalol is a prescription drug that treats arrhythmia.
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The primary outcome was a composite of death occurring at any time after randomization or ventricular tachycardia storm (three or more documented episodes of ventricular tachycardia within 24 hours) or appropriate ICD shock after a 30-day treatment period.
Japanese Ministry of Health, which used only dry weight in their calculations, confirmed by a phone interview of one of us (GEA) on June 21, 2005, with officials of this organization.
Patients with severe ventricular tachyarrhythmias were excluded from these post-infarction trials, however, and the suppression of arrhythmia in itself was not the primary objective of therapy.
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In addition, these patients may be refractory to the usual doses of epinephrine used to treat acute hypersensitivity reactions and may require a beta-agonist such as isoproterenol.
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The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else.
All other physical examination results were normal however the patient got worse during the physical exam and condition deterioratedSource: Heitz, Cory.
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Before using sotalol, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (QT prolongation in the EKG, history of torsade de pointes), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
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Effects of verapamil and propranolol on early after depolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome.
An intravenous beta blocker may be used to provide ventricular rate control in AF.
Sotalol is a commonly used antiarrhythmic drug that has been commercially available since the mid 1980's.
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You may be taking aspirin or clopidogrel (Plavix), warfarin (Coumadin), heparin, or another blood thinner such as Apixiban (Eliquis), Rivaroxaban (Xarelto), Dabigatran (Pradaxa) to help keep your blood from clotting.
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Use this medication as directed by your doctor, usually once daily.
Maximum safe dosages have not been established for young children.
suppressive antiarrhythmic therapy with sotalol or amiodarone may be required
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Amiodarone was better than sotalol, but its superiority only became evident after the six month point.
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Electrophysiology testing and catheter ablation are helpful when evaluating asymptomatic patients with Wolff-Parkinson-White pattern: the pro perspective.
For interpretation of the binary outcome results, differences in the absolute event rate were calculated using the GRADEpro software, for the median event rate across the control arms of the individual studies in the meta-analysis.
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BETAPACE (or SOTALOL) is not for everyone with irregular heartbeats (atrial fibrillation).
sotalol is the heart beat more slowly and evenly
Before taking sotalol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
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Behavioral and biological effects of oral magnesium, vitamin B6 and combined magnesium-vitamin B6 administration in autistic children.
Class Ia antiarrhythmic drugs, such as disopyramide, quinidine and procainamide and other Class III drugs (e.
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Therefore, we performed a thorough review of the literature to provide estimates of adverse events and toxicities with acute and long term administration of sotalol and amiodarone that should be considered when administering these drugs to patients for conversion of AF and to maintain NSR.
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Enter the date of the recommended first INR follow-up test after discharge documented in the medical record.
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LBBB) in the presence of either pre-existing BBB or AV conduction over an accessory pathway or when class Ic or class Ia antiarrhythmic drugs are used.
Chronic therapy often requires use of calcium-channel blockers, as there is no role for DC cardioversion, antiarrhythmic drugs, or ablation.
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In these studies, conversion rates of atrial flutter were not related to duration of the arrhythmia.
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In ICD recipients amiodarone and ablation therapy may play an important role in the reduction of device therapy.
Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) Trial.
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Class Ia, Ic, or III medications has been used in refractory cases.
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Many centers then follow sotalol patients on a quarterly basis to reassess renal function, observe QT intervals, and watch for new drug interactions.
Because atrial electrodes are usually left in place after cardiac surgery, atrial overdrive pacing for conversion to sinus rhythm is often a useful therapeutic technique to restore sinus rhythm.
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Sinus tachycardia results from physiological influences on individual pacemaker cells and from an anatomical shift in the site of origin of atrial depolarization superiorly within the sinus node.
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The clinical results of treatment with amiodarone in patients with ventricular tachyarrhythmias, as compared with the results of treatment with other drugs, have suggested that amiodarone may improve survival, but these results are from studies that were not prospectively controlled with random assignment to antiarrhythmic-drug therapy.
Long-term cost-effectiveness of alternative management strategies for patients with life-threatening ventricular arrhythmias.
Management of Patients with Ventricular Tachyarrhythmias: Does an Optimal Therapy Exist?
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It's predominately used for patients that have top chamber abnormalities called atrial fibrillation, which is the most common abnormal heart rhythm that we see, but it's also sometimes used for patients that have bottom chamber abnormalities, such as premature complexes from the bottom chamber--what we call PVCs or ventricular tachycardia.
Betapace AF ( hydrochloride) is a beta-blocker used to help keep the heart beating normally in people with of the (the upper chambers of the heart that allow blood to flow into the heart).
Shake the oral liquid well just before you measure a dose.
It is reasonable to perform AV node ablation with ventricular pacing to control heart rate when pharmacological therapy is insufficient or not tolerated.
Yes: QT interval was measured prior to discharge after 5 doses of newly initiated or dosage increase of dofetilide or sotalol.
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Drugs are listed alphabetically.
Examples include desipramine, ketoconazole, orlistat, phenobarbital, phenytoin, rifampin, and certain HIV protease inhibitors (such as ritonavir, tipranavir), among others.
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Brand-name Betapace and Betapace AF are made by Bayer HealthCare Pharmaceuticals, Inc.
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It's very important to take these medications exactly as prescribed.
Atrioventricular block may complicate slow-pathway ablation caused by posterior displacement of the fast pathway, superior displacement of the slow pathway (and coronary sinus), or inadvertent anterior displacement of the catheter during RF application.
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It is important that when you go home, you take the exact dose the doctor prescribed for you.
The CHADS(2) score predicts ischemic stroke in the absence of atrial fibrillation among subjects with coronary heart disease: Data from the Heart and Soul Study.
Advice from other commenters on this website is not a substitute for medical attention.
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